KMID : 0032220120240030295
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Annals of Dermatology 2012 Volume.24 No. 3 p.295 ~ p.305
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The Efficacy and Safety of 17¥á-Estradiol (Ell-Cranell¢ç alpha 0.025%) Solution on Female Pattern Hair Loss: Single Center, Open-Label, Non-Comparative, Phase IV Study
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Kim Jae-Hong
Lee Sung-Yul Lee Hae-Jin Yoon Na-Young Lee Won-Soo
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Abstract
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Background: There are several commercially available agents to treat female pattern hair loss (FPHL), including minoxidil solution, anti-androgen agents and mineral supplements. However, these treatments are not always satisfactory. We report the results of a clinical trial of 17¥á-estradiol (Ell-Cranell¢ç alpha 0.025%) solution to Korean female patients with FPHL.
Objective: This study was designed to examine the efficacy and safety of Ell-Cranell¢ç alpha 0.025% solution in Korean female patients with FPHL.
Methods: A total of 53 women, 18 to 55 years old, applied topical Ell-Cranell¢ç alpha 0.025% solution once daily for 8 months. Efficacy was evaluated by the change of hair counts and diameter, subjective assessment, and photographic assessment by investigators.
Results: Hair counts and diameter from baseline to 4 and 8 months after treatment increased in treated patients and these changes were statistically significant (p£¼0.0001). 17¥á-estradiol (Ell-Cranell¢ç alpha 0.025%) solution showed significant improvement by subjective self- assessment and by investigator photographic assessment. Ell-Cranell¢ç alpha 0.025% solution was well tolerated over 8-months period.
Conclusion: This study showed that Ell-Cranell¢ç alpha 0.025% solution is a safe and effective agent for Korean women with FPHL. (Ann Dermatol 24(3) 295¡305, 2012)
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KEYWORD
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17¥á-estradiol, Ell-Cranell¢ç, Female pattern hair loss
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